In developing
countries, people more rely on herbal based medicine for primary health care. In
recent years, herbal medicine and their active components are gaining
popularity to encounter various metabolic diseases such as obesity, heart disease
and diabetes etc., (Butt et al 2009).
In generally believe that herbal medicines are natural, no toxic or side effects
and immensely contribute to health benefits (Adeyemi et al 2014). 

sativum, commonly known as garlic is one of the ancient medicinal
herbs and most heavily studied herbs over the past several decades and the report
is mostly good.  Garlic holds a unique
active substance which contributes to wide range of pharmacological effect including
anti hyperlipidemic effect (Majewski,
2014). There is evidence that hypolipidemic influences of garlic shows
significantly reduce serum and hepatic total cholesterol, triglyceride, and
low-density lipoprotein levels and increase serum high-density lipoprotein
levels (Niaz et al, 2016; Uday Singh et
al 2015).

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Cow ghee or
clarified butter from milk solid could be consumed as food and as medicine. It
contains high energy, essential fatty acids and fat soluble vitamins (Ganguli and Jain 1973). Cow ghee is a traditional
medicine in Ayurveda and which are practiced for thousands of years, apart from
its role in the daily use of culinary purposes and traditional religious rituals.
Cow’s ghee holds numerous medicinal properties which are described in traditional
texts. Karandikar et al 2016; Shukla and
Tripathi 2006; Murthy Srikantha et al 1998). Despite this fact, ghee
contains higher amount saturated fatty acids which causes cardiovascular risks
were reported. Evidence on the health effects of ghee and garlic are individually
reported by Indian system of medicine, which discusses the possible benefits. However,
there is no scientific data has been made in regard to the hypolidemic of
garlic and its combination with ghee. These spurt interest to develop a dietary
intervention of Garlic infused ghee to explore their synergistic therapeutic effects
in rodent model.