Age is one of the most importantprognostic indicators in carcinoma breast especially the menopausal age. No ofhormonal changes and hormonal therapy after menopause affect the prognosis ofdisease. Prognosis is better in older age group as compared to young women(Dirier et al). In current study mean age was 33 yearsand 42.9% women were below 33 years.
In our study most of women were lying inage group of 33 to 48 years. This is consistent with the data found in localliterature. In our part of world, carcinoma breast is more common inpremenopausal age group, whereas in western countries, it is more common inpostmenopausal women. In countries likePakistan Women of the middle age group (30–59 years) are at a higher risk ofdeveloping breast cancer(Naeem et al).
Otherlocal studies has found this age group to be the commonest(Baloch et al). In current study the most common tumour typewas found to be infiltrating ductal carcinoma, as also found in national andinternational literature(Zahra et al).Lymph node status is also avaluable indicator of prognostic significance. Current study has found thatmost of the women are presenting in advance nodal disease (63.9%). This iscontradictory to the international literature, which showed relatively fewer premenopausalwomen or younger women in advance nodal disease. Like In one study 54% of thepatients had no lymph node metastasis, 21% had metastasis in range of 1-3 lymphnodes and 25% had more than three involved lymph nodes(Qureshiet al).
One local study showed 40% of patients had metastasis in morethan three lymph nodes(Naeem et al). Thisdifference in national and international literature is because of lack ofproper screening programs in underdeveloped countries like Pakistan.Previous studies especially fromwestern countries has shown increased incidence of carcinoma breast amongpostmenopausal women, mostly because of the screening programs targeted at thisage group, and post-menopausal hormonal therapy(Loiuset al).
Therefore patters and characteristics of carcinoma breast havebeen extensively studied in postmenopausal women, but much less attention hadbeen given to premenopausal women. Current study has focused on premenopausalwomen.ConclusionCarcinoma breast is more common in premenopausal age groupin our part of world. Late presentation with advanced disease warrants morefocused attention on premenopausal women group.