It is important to us that you first take time to read through and understand the information provided in this sheet. It will explain the purpose of the research, procedures and risks involved. It will also describe the information we will need to obtain from you, how that information will be used and with whom it will be shared with.Nevertheless, before you take part in this research study, the study will be explained to you and you are encouraged to ask questions about anything that you don’t understand, or want to know more about. Before deciding whether or not to take part, you might want to talk about it with a relative, friend or your local doctor. Participation in this research is voluntary. If you don’t wish to take part, you don’t have to. You will receive the best possible care whether or not you take part.After you are properly satisfied that you understand this study, and that you wish to take part in the study, you must sign this informed consent form. By signing it you are telling us that you:• Understand what you have read• Consent to take part in the research project• Consent to have the tests and treatments that are described• Consent to the use of your personal and health information as describe.You will be given a copy of this consent form to take home with you.Diabetes is a worldwide epidemic, where the number of people with diabetes is great in numbers and is constantly on the rise in every country of the world (World Health Organization, 2016). Diabetes itself is not fatal in the short term, however if uncontrolled, it will be a major risk factor for other serious medical problems such as heart attacks, stroke, blindness, gangrene and kidney failure (National Registry Of Diseases Office, 2016). Diabetes in Singapore is a major health crisis as 1 in 9 Singaporeans aged 18 to 69 suffer from diabetes, making up a total of 11.3% of the entire nation (Baker, 2017). Today, it is the leading cause for blindness, kidney failure, amputations, heart failure and stroke among adults. Life lost due to mortality and ill-health related to diabetes was the 10th largest among all diseases in 2017 (Ministry of Health Singapore, 2017). In 2015, a report by the International Diabetes Federation (IDF) revealed that Singapore had the second-highest proportion of diabetics behind the United States among developed nations. Over 90 per cent of diabetics in Singapore suffer from Type 2 diabetes, which is a result of insulin resistance, where the body is unable to utilise insulin needed to maintain blood glucose at normal levels properly (Lim, 2016). Type 2 diabetes is mainly due to poor lifestyle habits and obesity. Among the major racial groups in Singapore the incidence of diabetes is 2.5 in 10 Chinese, 5 in 10 Malays and 6 in 10 Indians, over the age of 60. highest among Indians, with an alarming 17.2 per cent of Indians affected (Khalik, 2017). We hope that the possible treatment in this study will help you, but this cannot be guaranteed. However, the information we get from this study may help us to treat future patients with Type 2 Diabetes better. The purpose of this study is to see whether,The other reason that we are doing this research is to study• Explain the research briefly in layman’s terms• The language used should clarify rather than confuse. • Avoid using jargon and technical terms e.g. pathogenesis, vectors, biochemical indicators etc. 6. Participant Selection and number of participants recruitedInclusion criteria: • Participant must have clinically diagnosed Type 2 Diabetes Mellitus that is mild (A1C of 7%) and well controlled.• Participant must be willing and able to undergo an informed consent process, and voluntarily sign and date the informed consent form.• Participant must be, Indian, male and between the ages of 35 to 55 years old.• Participants must be willing and able to have the types of diagnostic procedures required by the protocol, such as a variety of blood tests, and other testing.• Participant must be able to speak and read English well. Exclusion criteria: • Participant must not have severe form of Type 2 Diabetes Mellitus (A1C is above 9%)• Participant must not have concurrent medical conditions, as well as, any cognitive and mental impairment• Participant must not have a medical history of sensitivity, intolerance, or toxicity to the drug class Meglitinide.• Participant must not have a history of allergic/ hypersensitivity reaction to any prior drug or supplement of any kind.• Participant must not have a history of drug or alcohol abuse/addiction within the past 5 years• Participant must not anticipate a reasonable likelihood of vacations OR other times away from home OR moving away from the research site.• Participant must not suffer from needle phobia (fear of injection needles)7. Type of Research Intervention, procedures and protocols – divided into TWO sections (A) Unfamiliar Procedures A method known as stratified sampling has been used for the selection of volunteers, whereby volunteers were grouped accordingly to their race (Chinese, Malay and Indian) before a random selection was performed. If you choose to take part in this study, you will be randomly assigned into two study groups within your racial group. The two study groups are: the experimental group and the control group. A computer programme will be used to give you an equal chance of being assigned to one of the two study groups. The experimental group will be receiving the MEG2943 monotherapy that is being tested, while the control group receives the Repaglinide (Prandin) monotherapy, a conventional treatment that is currently the gold standard. Also, this study will be double-blinded, which means both yourself and your doctor will be unaware of which of the two treatments you will receive. This is to prevent any conscious or unconscious biasness in the execution of the clinical trial.(B) Description of the procedureIf you take part in this study, you will be asked to undergo blood tests, urine tests, as well as, attend a number of interviews and follow-up sessions.Tests: I. Fasting blood glucose level:This test measures your blood sugar level, to see if the drugs is efficacious at maintaining levels in the normal range. You will have your blood drawn at an early morning doctor’s visit after fasting overnight. II. Haemoglobin A1c (A1C) test:This test measures how much sugar is stuck to your red blood cells, which generally have a lifespan of three months. Therefore, this test gauges how high your blood sugar has been in recent months.III. Oral glucose tolerance test This test measures how your body handles sugar. You will have your blood drawn once, then you will be required to drink a syrupy glucose solution, after which you will have your blood drawn at 30 to 60 minute intervals for up to three hours.IV. Urine dipstick testThis test detects glucose in a sample of urine. You will be required to collect a small amount of your urine in a container provided to you. A special chemical strip will simply be dipped into a sample of your urine, and colour changes on the strip will show whether there is glucose in the urine sample.Confidentiality:Your records relating to this study and any other information received will be kept strictly confidential. However, staff participating in your care, the sponsor and other agencies authorised by law, may inspect the records related to the study. In the event you are admitted to hospital as a result of an adverse event resulting from this study, your treating doctor may require access to your study records. Your identity will not be revealed and your confidentiality will be protected in any reviews and reports of this study which may be published. 8. Risks and discomfortsRisk and discomfort associated with test drug:Allergic reactions can occur with any drug. Common symptoms may include: rash, itching etc.Rarely, a severe and possibly life-threatening allergic reaction can occur. Symptoms of a severe reaction include: swelling of the face, difficulty breathing, or a sudden drop in blood pressure that may cause dizziness. If you have any of these symptoms, call your doctor at once.(Intervention or investigation) is still being tested; therefore, you may experience other side effects that have not yet been reported. However, you will be kept informed of any significant new findings that may relate to your willingness to continue to take part in this study.Risks and discomfort associated with a blood collection: You may experience a problem during or after a blood test, although the chances of that are very low chance. The possible risks include:• Multiple puncture wounds (if a vein is difficult to find)• Excessive bleeding• Lightheadedness or fainting• Bruises, or blood collecting under your skin• Infection• Explain and describe the possible or anticipated risks or discomforts the subjects may experience. • Ensure that sufficient information may be provided to allow the participant to make an informed decision 9. Duration of the research Your participation in the study will last (Insert length of time subject will be required for the study). You will (take the study medication / use the study device) for about (Insert number of times study intervention will be performed) and be followed up for (State length of time of follow-up within the study). You will need to visit the doctor’s office (State number of times) times in the course of the study.If you agree to take part in this study, the following will happen to you:Schedule of visits and procedures: Visit 1:Visit 2, 3 (Weeks ___, ___) etc.Final Visit (Week ___)Follow-up: The follow-up part consists of (state number of contacts)• Include a statement about the time commitments of the research for the participant including both duration of the research and follow-up (if relevant). 10. Side Effects Medical treatments often cause side effects. You may have none, some or all of the effects listed below, and they may be mild, moderate or severe. If you have any of these side effects, or are worried about them, talk with your study doctor. Your study doctor will also be looking out for side effects. There may be side effects that the researchers do not expect or do not know about which may be serious. Tell your study doctor immediately about any new or unusual symptoms that you experience. Many side effects go away shortly after treatment ends. However, sometimes side effects can be serious, long lasting or permanent. If a severe side effect or reaction occurs, your study doctor may need to stop your treatment. Your study doctor will discuss with you the best way of managing any side effects you may experience.• Subjects should be made aware of the known or anticipated side effects and actions taken by the institution in the event of a side effect or an unexpected event. 11. Reimbursements You will not be paid for participating in this project. However, all medication and study-related tests will be provided at no cost to you. The cost of travel can either be met by reimbursement of petrol costs or the use of taxi vouchers. Reimbursement of parking is also provided.12. Right to Refuse or WithdrawThere is absolutely no obligation for you to be involved in this study. If you do not participate your normal treatment plan will be followed. If you decide to participate in the study and later feel that you no longer wish to be part of it, you may withdraw from the study at any time without prejudice to any current or future medical treatment.