The article, “Application of Proteomics in Acute Graft-Versus-Host DiseaseManagement: An Integrative Review and Nursing Implications,” has a mainfocus of identifying the research conducted on graft-versus-host disease(GVHD). The disease can be a life-threatening disease, most commonly occurring inpatients who have undergone hematopoietic stem cell transplantation. Hematopoieticstem cell transplantation (HSCT) is a procedure that involves an intravenous(IV) infusion of either autologous or allogeneic stem cells to reestablishhematopoietic function in individuals whose bone marrow or immune system is damaged(“Hematopoietic Stem CellTransplantation,” 2017). The article emphasized on how nearly 50 percent ofpatients who receive HSCT often times have results of poor prognosis. There aremany cases where this type of procedure is used; most commonly the procedure isused with patients who have multiple myeloma, non-Hodgkin disease, neuroblastoma,and in patients who have germ cell tumors.

            The reading included biomarkers, andbarriers that are involved in the assessment of detecting GVHD in patients inthe healthcare setting, as well as reviewing the biomarker research results onacute and chronic GVHD. This research was gathered from studying urine, saliva,and peripheral blood. For example, one of the biomarkers included in the readingis body fluid. Body fluid is one of the noninvasive sources of biomarkers, andthe protein, ST2 was recently demonstrated as one of the important biomarkersfor therapy responses and death responses that would avoid relapse (Kalariya,N., & Brassil, K, 2015).

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Furthermore, biomarkers are crucial factors indetermining whether or not the patient will survive.             Inthe article, there are very unbiased studies as well as proteomic studies thatinclude features of both of the diseases, as well as the role of immune cellpopulations. There are many risk factors that are targeted within the reading,determining potential life-threatening risks involved in the procedure.